The isolation of 17-ketosteroids from the urine of normal women

Abstract

Aetiocholan-3([alpha]a)-01-17-one (1.3 mg./1), androsterone (1.3 mg./l) and transdehydroandrosterone (0.2 mg./l) have been isolated from extracts of the urine of normal [female][female]. These yields are comparable with those of the same compounds from normal [male] urine. Androsterone is the principal andro-genic compound in extracts from the urine of either sex. Although urinary aetiocholan-3([alpha])-01-17-one and androsterone are known to be derived from testosterone when this has been given by inj., it does not follow that their presence in urine indicates the secretion of testosterone by [female][female].