Limited Degradation of Gelatin Substrate by Cathepsin D
- 1 January 1972
- journal article
- research article
- Published by Taylor & Francis in Connective Tissue Research
- Vol. 1 (2), 103-108
- https://doi.org/10.3109/03008207209152062
Abstract
Cathepsin D has been demonstrated to degrade the protein backbone of proteinpolysaccharide. In this study we present evidence that cathepsin D has only a limited yet specific capacity to degrade gelatin. Similar to the effects of pepsin on collagen, cathepsin D degraded β chains of pure gelatin to α chains but showed no capacity to cleave at a site other than the N-terminal cross-link region. These data suggest that it is unlikely that cathepsin D has a major role in any phase of collagenolysis.Keywords
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