The Response of the Renal Circulation in Man to Constant-Speed Infusions of l -Norepinephrine

Abstract

The effects of constant-speed intravenous infusions of l -norepinephrine in man have been studied with reference to the changes produced in the renal circulation. The responses to four rates of infusion were studied both qualitatively and quantitatively in each of nine normal men. As dosage was increased glomerular filtration rate changed little if at all, effective renal plasma flow diminished, and filtration fraction rose. Both afferent and efferent glomerular arteriolar resistances sharply increased, but the latter did so much more markedly than the former.