Low Density Lipoprotein Receptor Activity in Human Leukemic Cells-Relation to Chromosome Aberrations
- 24 April 2009
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 217 (5), 553-558
- https://doi.org/10.1111/j.0954-6820.1985.tb03262.x
Abstract
Chromosome analysis and low density lipoprotein (LDL) receptor activity of leukemic cells from 38 patients with acute non-lymphocytic leukemia were correlated. Clonal chromosome aberrations were found in 22 patients; an extra chromosome 8 was found in 7 of them. LDL receptor activity was significantly higher in patients with an extra chromosome 8 than in patients with other abnormalities or a normal karyotype. Chromosome 8 may harbor genes of importance for the expression of the LDL receptor.Keywords
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