Hemolytic anemia in the mouse

Abstract

A new mutation causing spherocytic, hernolytic anemia has been discovered in the house mouse. It is Inherited as a single autosornal recessive gene, allelic with both sph and ha, which, in turn, were shown to be allelic with each other. A revised nomenclature for the three apparent alleles is proposed: sph (formerly sph), sph^ha (formerly ha), and sph^2Bc (the new mutation). Like the other murine hemolytic anemias, sph^2Bc involves a defect in the red blood cell membrane protein, spectrin.