For many years, cases of lymphogranuloma inguinale have been reported individually or in small groups under a variety of more or less descriptive names. The literature on this subject has been completely reviewed by Stannus1in his recent book and need not be dealt with here. With the advent of the Frei test2and its rather widespread use and acceptance, the clinical and public health importance of this disease is only just beginning to be appreciated. The only large series reported in this country is that of DeWolf and Van Cleve,3who found fiftyeight positive cases in 1,010 persons tested with the Frei antigen. In St. Louis the first case was described in 1933 by Ives and Katz.4In 1935 Rainey and Cole5reported twenty-three cases. In our studies we have tested out, by means of the Frei reacaction, the incidence of lymphogranuloma inguinale