Expression of Murine Ia Antigens during Embryonic Development
- 1 March 1978
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 120 (3), 818-824
- https://doi.org/10.4049/jimmunol.120.3.818
Abstract
An immunochemical analysis of the kinetics of appearance of Ia antigens during embryonic development was performed. Ia antigens first appear on the surface of embryonic cells 11 days postconception and their expression between days 11 and 16 of gestation is confined to the fetal liver. Ia antigen synthesis by fetal liver cells is detectable at day 14. Ia seems to precede Ig as a surface marker of embryonic liver cells, since Ig cannot be detected until day 16 of gestation. H-2 antigens may be immunoprecipitated from day 10 whole embryo cells. F9 primitive teratocarcinoma cells are Ia negative and H-2 negative.This publication has 5 references indexed in Scilit:
- Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice.The Journal of Experimental Medicine, 1977
- Characterization of B cell subpopulations by velocity sedimentation, surface la antigens and immune functionEuropean Journal of Immunology, 1977
- Expression of Ia antigens on hapten-specific B cells. I. Delineation of B-cell subpopulations.The Journal of Experimental Medicine, 1976
- An Improved Method for Isolation of H-2 and Ia Alloantigens with Immunoprecipitation Induced by Protein A-Bearing StaphylococciThe Journal of Immunology, 1976
- Fetal Liver: A Source of Immunoglobulin Producing Cells in the Mouse.Experimental Biology and Medicine, 1967