Human Leukemic Cells: In vitro Growth of Colonies Containing the Philadelphia (Ph 1 ) Chromosome
- 10 December 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4014), 1134-1136
- https://doi.org/10.1126/science.174.4014.1134
Abstract
Human leukemic cells with a marker (Philadelphia; Ph1) chromosome gave rise to granulocytic and mononuclear cell colonies when grown in vitro. All metaphases from a single colony were either Ph1 positive or Ph1 negative. No colonies contained a mixed cell population. This suggests that leukemic and normal cells exist simultaneously and that in vitro colonies are clonal in origin.Keywords
This publication has 10 references indexed in Scilit:
- Granulopoiesis in Acute Myeloid Leukemia and PreleukemiaNew England Journal of Medicine, 1971
- Distinguishing between the Chromosomes involved in Down's Syndrome (Trisomy 21) and Chronic Myeloid Leukaemia (Ph1) by FluorescenceNature, 1971
- Cells Capable of Colony Formation in the Peripheral Blood of ManScience, 1971
- In Vitro Induction of Granulocyte Differentiation in Hematopoietic Cells from Leukemic and Non-Leukemic PatientsProceedings of the National Academy of Sciences, 1970
- Bone Marrow Colonies: Stimulation in vitro by Supernatant from Incubated Human Blood CellsScience, 1970
- Human bone marrow colony growth in agar‐gelJournal of Cellular Physiology, 1970
- Chromosomal Abnormalities in Human NeoplasiaAnnual Review of Medicine, 1970
- THE GROWTH OF MOUSE BONE MARROW CELLS IN VITROImmunology & Cell Biology, 1966
- The Philadelphia Chromosome and Chronic Myelogenous LeukemiaJNCI Journal of the National Cancer Institute, 1966
- Chromosome preparations of leukocytes cultured from human peripheral bloodExperimental Cell Research, 1960