The problem of isolated cases of Huntington's disease in South Wales 1974-1984
- 23 April 2008
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 30 (5), 433-439
- https://doi.org/10.1111/j.1399-0004.1986.tb01903.x
Abstract
A firm diagnosis of Huntington''s Disease (HD) is based upon both clinical observation and a positive family history. 192 cases of HD occurred in South Wales over a 10 year period fitting both criteria but an additional 37 patients did not have affected relatives despite detailed enquiries. Twenty-two of these were still thought to have HD on clinical grounds whilst this diagnosis was thought less likely for 15. Definite post-mortem outcomes are known for 7 patients and the clinical diagnosis confirmed on 6 occasions. Details regarding these two groups are presented together with an additional case in which HD was given on the death certificate but a post-mortem revealed a diagnosis of Kufs'' disease.Keywords
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