Long-term potentiation of Aplysia sensorimotor synapses in cell culture: regulation by postsynaptic voltage
- 22 February 1994
- journal article
- research article
- Published by The Royal Society in Proceedings Of The Royal Society B-Biological Sciences
- Vol. 255 (1343), 113-118
- https://doi.org/10.1098/rspb.1994.0016
Abstract
Long-term potentiation (LTP) has been proposed as a cellular mechanism for associative learning in vertebrates. Induction of one type of LTP--observed at synapses in the CA1 region of the mammalian hippocampus--is regulated by the voltage of the postsynaptic cell. To date, a similar form of LTP has not been demonstrated for any invertebrate synapse. We now report that high-frequency stimulation can induce LTP of sensorimotor synapses of the marine mollusc Aplysia in cell culture. Moreover, induction of this form of LTP appears to involve a voltage-dependent postsynaptic mechanism because pairing tetanic stimulation of the presynaptic cell with strong hyperpolarization of the postsynaptic cell blocks the induction of LTP.Keywords
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