Incorporation of 5-Iododeoxyuridine131I in Spontaneous C3H Mouse Mammary Tumours

Abstract

131I incorporation in spontaneous mammary tumors and other organs of C3H mice was examined as a function of time following the administration of 131I UDR. After a period of four days, the tumors were labelled with higher specific acitivty than any other tissue. The absolute amount of incorporation was increased by pretreatment with FUDR and by subcutaneous rather than intraperitoneal injection. CDR administered with the IUDR did not increase incorporation. A possible explanation for these findings was given. The results of the study were sufficiently encouraging to justify a clinical trial of 131I UDR in the localisation of human tumors with our whole body scanner.