The serotonin receptor subtype 2 locusHTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14

Abstract

Serotonin (5-hydroxytryptamine) functions as a neurotransmitter and a hormone. Its diverse actions are mediated by at least seven distinct cell surface receptor subtypes. The serotonin receptor subtype 2 (gene symbolHTR2) is a G-protein-coupled receptor, expressed primarily in the cerebral cortex, where upon stimulation it stimulates the hydrolysis of inositol phospholipids. We have mapped theHTR2 locus to human chromosome 13 and to mouse chromosome 14 by somatic cell hybrid analysis. Linkage studies in CEPH families, using a PvuII RFLP detected with the HTR2 probe, revealed tight linkage betweenHTR2 andESD, the locus for esterase D. The most likely position forHTR2 is betweenESD andRB1, the retinoblastoma-1 gene. The homologous loci in mouse,Rb-1 andEsd(Es-10) are on mouse chromosome 14, close toag, agitans, a recessive neurological mutation. Having mappedHtr-2 to mouse chromosome 14, we predict that it falls into this known conserved gene cluster.