Reduction of Tumorigenicity of Cigarette Smoke

Abstract

A study of different types of cigarettes has demonstrated that the tumorigenic activity of cigarette smoke condensate for the experimental animal can be significantly reduced through practical means. It has been shown that a combination of modifications in the makeup of cigarettes, with respect to reduction of total smoke condensate yield, selective reduction of tumorigenic agents, and selective reduction of ciliotoxic agents, can significantly lower the tumorigenic as well as the ciliotoxic activity of cigarette smoke condensate established to a variety of animals and animal tissue. It has been stressed that long-term epidemiologic studies on man are necessary to determine the effect of these changes on the development of those types of cancer considered to be associated with cigarette smoking.