Concanavalin A potentiates syngeneic response in murine lymphocytes.
Open Access
- 1 January 1976
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 143 (1), 1-14
- https://doi.org/10.1084/jem.143.1.1
Abstract
Lymphocytic choriomeningitis or vaccinia virus-immune spleen cells of H-2 mutant mice carrying a point mutation in the K region (B6 H-2ba, B6 H-2bf) cannot lyse infected wild-type H-2Kb targets and vice versa. Yet, cytotoxic T cells specific for infected H-2Kba or H-2Kbf targets are generated during virus infections as shown by cold target competition experiments. The critical structure for the apparent restriction by the K or D regions of the H-2 gene complex of cytolytic interactions between T cells and virus-infected target cells are therefore each coded, at least as shown for the K region, by a single cistron. This finding is most readily accommodated within the altered self concept (postulating that T cells are specific for virus-modified self structures) but cannot exclude the possibility of a physiological interaction mechanism being responsible for the apparent H-2 restriction of virus-specific cytotoxic T cells.Keywords
This publication has 24 references indexed in Scilit:
- Proliferation of mouse bone marrow-derived lymphocytes in vitro: One mechanism of response to concanavalin A and phytohemagglutininCellular Immunology, 1975
- Mixed lymphocyte reactivity and cell-mediated lympholysis to trinitrophenyl-modified autologous lymphocytes in C57BL/10 congenic and B10.A recombinant mouse strainsThe Journal of Experimental Medicine, 1975
- Study of the cells proliferating in parent versus F hybrid mixed lymphocyte culture.The Journal of Experimental Medicine, 1975
- Concanavalin A: Its Action in Inducing Oocyte Maturation-Inducing Substance in Starfish Follicle CellsScience, 1975
- Evidence for a B-cell -like helper function in mixed lymphocyte culture between immunocompetent thymus cells.The Journal of Experimental Medicine, 1975
- EVIDENCE FOR IDENTITY OR CLOSE ASSOCIATION OF THE Fc RECEPTOR OF B LYMPHOCYTES AND ALLOANTIGENS DETERMINED BY THE Ir REGION OF THE H-2 COMPLEXThe Journal of Experimental Medicine, 1974
- Expression of M locus differences by B cells but not T cellsNature, 1974
- Editorial: Immune activation of B cells: evidence for 'one nonspecific triggering signal' not delivered by the Ig receptors.1974
- BIOLOGICAL EFFECTS OF MURINE HISTOCOMPATIBILITY ANTIGEN SOLUBILIZED WITH 3 M POTASSIUM CHLORIDETransplantation, 1973
- Protein-Carbohydrate Interaction. II. Inhibition Studies on the Interaction of Concanavalin A with Polysaccharides*Biochemistry, 1965