SOME EPISTATIC 2-LOCUS MODELS OF DISEASE .1. RELATIVE RISKS AND IDENTITY-BY-DESCENT DISTRIBUTIONS IN AFFECTED SIB PAIRS
- 1 January 1981
- journal article
- research article
- Vol. 33 (3), 381-395
Abstract
A 2-locus disease model is presented in which a marker locus interacts epistatically with another unlinked trait to cause the disease. Such a model can lead to disease-marker associations and distortions in the sharing of marker types among affected family members. These effects are quantified. In HLA-disease associations, this model is presented as an alternative to the hitchhiking theory of tight linkage leading to linkage disequilibrium.This publication has 36 references indexed in Scilit:
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