A Metaregression Analysis of the Dose-Response Effect of Aspirin on Stroke
Open Access
- 14 June 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 159 (11), 1248-1253
- https://doi.org/10.1001/archinte.159.11.1248
Abstract
EXPERTS DISAGREE about the optimal aspirin dose in preventing stroke. Patrono and Roth1(p756) claim that "good clinical practice should dictate the use of the lowest dose of aspirin shown effective in the prevention of stroke and death in patients with ischemic cerebrovascular disease, i.e., 75 mg daily." Barnett et al2(p590) believe otherwise: "We postulate that the evidence is uncertain and available only from indirect comparisons but that it leans toward the moderate- to higher-dose regimens."Keywords
This publication has 4 references indexed in Scilit:
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- Swedish Aspirin Low-dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic eventsThe Lancet, 1991
- Secondary prevention of vascular disease by prolonged antiplatelet treatmentBMJ, 1988
- United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: interim resultsBMJ, 1988