Some Experimental Evidence of Production of Adrenotrophin by the Fetal Hypophysis.

Abstract

Fetal rats with placental circulation intact were given a series of subcut. injns. of Armour''s hypophyseal adrenotrophin, others were deprived of the hypophysis by decapitation and still others were subjected to both treatments. These injns. caused the fetal adrenal to grow more rapidly than in controls. Removal of the head inhibited the growth of the adrenal and caused abnormal changes in the cortical cells. Injns. prevented this inhibition and these changes. The observations may be taken as exptl. evidence of the production of adrenotrophin by the hypophysis of the fetal rat.