PREFERENTIAL LOSS OF MATERNAL ALLELES IN SPORADIC WILMS-TUMOR
- 1 November 1990
- journal article
- research article
- Vol. 5 (11), 1665-1668
Abstract
Loss of heterozygosity at loci on the short arm of chromosome 11 has been reported in 31% (11/38) of Wilms'' tumours in our series. Lymphoblastoid cell lines were prepared from the parents of 10/11 of the patients showing allele loss in their tumours. In 9 of the cases, where the parental origin of the alleles could be followed, it was the paternal alleles which were retained in the tumour. This preferential loss of the maternal alleles implies a role for genomic imprinting in the pathogenesis of Wilms'' tumour.This publication has 23 references indexed in Scilit:
- Beta-globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man.Proceedings of the National Academy of Sciences, 1983
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- Gene for Hereditary Retinoblastoma Assigned to Human Chromosome 13 by Linkage to Esterase DScience, 1983
- Hypomethylation of ras oncogenes in primary human cancersBiochemical and Biophysical Research Communications, 1983
- Isolation of a transforming sequence from a human bladder carcinoma cell lineCell, 1982
- The construction and partial characterization of plasmids containing complementary DNA sequences to human calcitonin precursor polyproteinBiochemical Journal, 1981
- Nucleotide sequence of cloned cDNAs encoding human preproparathyroid hormone.Proceedings of the National Academy of Sciences, 1981
- Polymorphic DNA region adjacent to the 5' end of the human insulin gene.Proceedings of the National Academy of Sciences, 1981
- DNA sequence variants in the Gγ-, Aγ-, δ- and β-globin genes of manCell, 1979
- Chromosomal Imbalance in the Aniridia-Wilms' Tumor Association: 11p Interstitial DeletionPediatrics, 1978