A second human calcitonin/CGRP gene
- 22 April 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 183 (2), 408-412
- https://doi.org/10.1016/0014-5793(85)80820-6
Abstract
The calcitonin (CT) gene is alternatively expressed in a tissue-specific fashion producing either the calcium regulatory hormone CT in the thyroid or the neuropeptide calcitonin gene related peptide (CGRP) in the brain. In medullary carcinoma of the thyroid both peptides are produced. We present here evidence for the existence in the human genome of a second CT gene, which is also expressed in human medullary thyroid carcinoma. This gene encodes a second human CGRP, differing from the known human CGRP in 3 of the 37 amino acids.Keywords
This publication has 11 references indexed in Scilit:
- Calcitonin gene-related peptide is a potent vasodilatorNature, 1985
- Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.Molecular and Cellular Biology, 1984
- Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptideBiochemical and Biophysical Research Communications, 1984
- CALCITONIN GENE RELATED PEPTIDE CODING SEQUENCE IS CONSERVED IN THE HUMAN GENOME AND IS EXPRESSED IN MEDULLARY THYROID CARCINOMAJournal of Clinical Endocrinology & Metabolism, 1984
- Calcitonin gene-related peptide in the human thyroid, pituitary and brainMolecular and Cellular Endocrinology, 1984
- Localization of the polymorphic human calcitonin gene on chromosome 11Human Genetics, 1984
- Isolation and characterization of human calcitonin gene-related peptideNature, 1984
- SALMON AND HUMAN CALCITONIN-LIKE PEPTIDES IN MANClinical Endocrinology, 1984
- SALMON AND HUMAN CALCITONIN-LIKE PEPTIDES COEXIST IN THE HUMAN THYROID AND BRAINJournal of Clinical Endocrinology & Metabolism, 1983
- A new method for sequencing DNA.Proceedings of the National Academy of Sciences, 1977