Effects of Bromocryptine on Hormone and Blood Pressure Levels in the Spontaneously Hypertensive Rat
- 1 June 1979
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 161 (2), 186-188
- https://doi.org/10.3181/00379727-161-40517
Abstract
Treatment of young and old male and female SH [spontaneously hypertensive] rats with bromoergocryptine (21 days) significantly reduced blood prolactin concentrations. Blood pressure was slightly depressed in young male SH rats but in females blood pressure was unchanged. Hypertension was reduced (30%) to normotensive levels in old rats of both sexes. Corticosterone levels were slightly affected by treatment. A significant drop in aldosterone levels was noted in young male SH rats exclusively. The hypotensive action of bromocryptine (a dopamine agonist) is uncertain but may be related to changes in catecholamine levels or actions within the CNS.This publication has 4 references indexed in Scilit:
- PLASMA PROLACTIN IN ESSENTIAL AND RENOVASCULAR HYPERTENSION1978
- Evidence for Depressed Catecholamine and Enhanced Serotonin Metabolism in Aging Male Rats: Possible Relation to Gondotropin Secretion2Endocrinology, 1977
- HYPERPROLACTINAEMIA AND ANTIHYPERTENSIVE EFFECT OF BROMOCRIPTINE IN ESSENTIAL HYPERTENSION - IDENTIFICATION OF ABNORMAL CENTRAL DOPAMINE CONTROL1977
- Pathological Studies on the Endocrine Organs of the Spontaneously Hypertensive RatsJapanese Heart Journal, 1963