The effect of structure of Mannich base prodrugs on their ability to deliver theophylline and 5-fluorouracil through hairless mouse skin
- 1 June 1988
- journal article
- research article
- Published by Elsevier in International Journal of Pharmaceutics
- Vol. 44 (1-3), 87-96
- https://doi.org/10.1016/0378-5173(88)90104-4
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Effect of Skin Pretreatment With Vehicle Alone or Drug in Vehicle on Flux of a Subsequently Applied Drug: Results of Hairless Mouse Skin and Diffusion Cell StudiesJournal of Investigative Dermatology, 1987
- Use of Theoretical Partition Coefficients Determined From Solubility Parameters to Predict Permeability Coefficients for 5-FluorouracilJournal of Investigative Dermatology, 1987
- Use of Solubility Parameters of Drug and Vehicle to Predict Flux Through SkinJournal of Investigative Dermatology, 1986
- Extended Hildebrand Solubility Approach: Sulfonamides in Binary and Ternary SolventsJournal of Pharmaceutical Sciences, 1985
- Mannich base derivatives of theophylline and 5-fluorouracil: syntheses, properties and topical delivery characteristicsInternational Journal of Pharmaceutics, 1984
- Hydroxymethyl and acyloxymethyl prodrugs of theophylline: enhanced delivery of polar drugs through skinInternational Journal of Pharmaceutics, 1982
- Pro-drugs as drug delivery systems XXIII. Improved dermal delivery of 5-fluorouracil through human skin via N-acyloxymethyl pro-drug derivativesInternational Journal of Pharmaceutics, 1982
- Hydrolysis of N-Mannich bases and its consequences for the biological testing of such agentsInternational Journal of Pharmaceutics, 1981
- A method for estimating both the solubility parameters and molar volumes of liquidsPolymer Engineering & Science, 1974
- Synthese und Eigenschaften einiger Mannichbasen des Theophyllins, 8‐Bromtheophyllins und TheobrominsArchiv der Pharmazie, 1965