Triamcinolone has the unique advantage that it is not a salt-retaining steroid, and therefore it has been found useful to physicians dealing with pharmacologic doses in serious diseases such as rheumatoid arthritis, lupus erythematosus, and the nephrotic syndrome. In the physiologic dosage ranges utilized in the adrenogenital syndrome, salt retention and other side effects are not complications of cortisone therapy. Our results would indicate that triamcinolone is 8 to 10 times as potent as cortisone when comparing adrenal suppressive ability. However, the increased potency of this compound is accompanied by a reduced margin of safety, and cortisone, hydrocortisone, or prednisone remain the drugs of choice in treatment of congenital virilizing adrenal hyperplasia.