Synthetic morphinans and hasubanans. VI. Total synthesis of 3-hydroxyisomorphinans, 3-hydroxyhasubanans, and 3,9-dihydroxyhasubanans

Abstract

A new total synthesis of racemic 3-hydroxyisomorphinans (3), 3-hydroxyhasubanans (9), 3,9α-dihydroxyhasubanans (5), and 3,9β-dihydroxyhasubanans (7), via 4a-(2-aminoethyl)-1,2,3,4,4a,9-hexahydro-6-methoxyphenanthrene (1a) is described.