A consensus epitope prediction approach identifies the breadth of murine TCD8+-cell responses to vaccinia virus
Top Cited Papers
- 11 June 2006
- journal article
- research article
- Published by Springer Nature in Nature Biotechnology
- Vol. 24 (7), 817-819
- https://doi.org/10.1038/nbt1215
Abstract
The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.Keywords
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