Influence of anesthesia on the response to carotid hypotension in dogs
- 1 October 1979
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
- Vol. 237 (4), H424-H432
- https://doi.org/10.1152/ajpheart.1979.237.4.h424
Abstract
The systemic hemodynamic response to carotid sinus hypotension (CSH) was obtained by bilateral common carotid or brachiocephalic artery occlusion in trained, chronically instrumented dogs lightly premedicated with morphine and atropine. Responses were obtained before and after anesthesia of equivalent dose by pentobarbital (PB, 30 min post), chloralose (C, 30 min post), or halothane (H, 120 min post). After induction, the animals were intubated and mechanically ventilated by positive pressure with 30% O2 in N2. In the steady state, mean arterial pressure was unchanged with C and PB but decreased with H (-22 .+-. 5%). Cardiac output was decreased by all 3 anesthetics: PB, -34 .+-. 4%; C, -25 .+-. 8%; and H, -13 .+-. 8%. The pressor response to CSH was diminished by all 3 anesthetic agents PB, 48 .+-. 4% to 19 .+-. 5%; C, 58 .+-. 10% to 32 .+-. 2%; and H, 44 .+-. 4% to 21 .+-. 6%. The magnitude of the pressor response to CSH increased with time under PB and C. The response was even more depressed early after induction and tended to return toward control as a function of time after induction, which was associated with recovery from anesthesia. The magnitude of the change in both mean and pulsatile carotid sinus pressure with CSH was larger after anesthesia than before. Apparently all 3 anesthetic agents depress the responses of peripheral baroreceptor-mediated reflexes.This publication has 12 references indexed in Scilit:
- Left Ventricular Function in Conscious Man and during Halothane AnesthesiaAnesthesiology, 1978
- Dose-dependent Depression of Cardiac Function and Metabolism by Halothane in Swine (Sus scrofa)Anesthesiology, 1977
- Canine Systemic and Cerebral Effects of Hypotension Induced by Hemorrhage, Trimethaphan, Halothane, or NitroprussideAnesthesiology, 1977
- VENOUS RELAXATION BY HALOTHANE ACTING ON SYMPATHETIC-NERVES1975
- ALTERATIONS IN MECHANICAL PROPERTIES OF HEART MUSCLE PRODUCED BY HALOTHANE1968
- EFFECTS OF ANESTHETICS ON CIRCULATORY REGULATORY MECHANISMS IN DOG1966
- Comparison of the reflex responses elicited by stimulation of the separately perfused carotid and aortic body chemoreceptors in the dogThe Journal of Physiology, 1966
- Stretch Reflexes from the Dog's Lung to the Systemic CirculationCirculation Research, 1959
- THE EFFECTIVENESS OF THE BARORECEPTOR REFLEXES UNDER DIFFERENT ANESTHETICS1956
- A comparison of the effects of pulsatile and non‐pulsatile blood flow through the carotid sinus on the reflexogenic activity of the sinus baroceptors in the catThe Journal of Physiology, 1952