Effect of Antimacrophage Serum on Hypersensitivity (Schistosoma Mansoni Egg) and Foreign Body (Divinyl-Benzene Copolymer Bead) Granulomas

Abstract

Antimacrophage serum (AMS) was obtained by immunizing rabbits with glassadherent mouse peritoneal exudate cells. The antiserum was repeatedly absorbed until free of antilymphocytic antibodies. Repeated injections of AMS into mice suppressed the level of circulating blood monocytes. AMS was toxic in vitro to peritoneal exudate cells. Repeated injections of AMS suppressed the delayed hypersensitivity granulomas that formed around eggs of Schistosoma mansoni injected into the microvasculature of the mouse lung. Similar injections of the antiserum, however, had no effect on the foreign body granulomas produced in response to similarly injected plastic beads.