Discussion and Summary Despite unquestionable evidence from the work of others that 2-deoxyglucose inhibits glucose oxidation in isolated tissues and eviscerated rabbits there was no impairment of disposition of a glucose load in adrenal-demedullated anesthetized rats pre-treated with large doses of deoxyglucose. This suggests that other pathways of glucose disposal must be utilized which compensate for inhibition of oxidation. These avenues of glucose disposal will be explored. Inhibition by DHE of the hyperglycemia which results from injection of deoxyglucose into intact fasted rats suggests that this glucose analogue is capable of stimulating release of epinephrine from the adrenal medulla. The lack of hyperglycemia following deoxyglucose injection in adrenal demedullated rats lends support to this hypothesis.