The dopamine hypothesis of schizophrenia: focus on the dopamine receptor
- 1 February 1976
- journal article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 133 (2), 197-202
- https://doi.org/10.1176/ajp.133.2.197
Abstract
Alleviation of schizophrenic symptoms by phenothiazines and butyrophenones is associated with blockade of dopamine receptors, while exacerbation of symptoms by amphetamines appears to result from enhanced synaptic activity of dopamine and/or norepinephrine. The author suggests that biochemical labeling of the dopamine receptor with 3H-dopamine and 3H-haloperidol may clarify mechanisms of drug effects on the dopamine receptor.Keywords
This publication has 17 references indexed in Scilit:
- Dopamine receptor binding: Differentiation of agonist and antagonist states with 3H-dopamine and 3H-haloperidolLife Sciences, 1975
- Phenothiazine drugs: structure-activity relationships explained by a conformation that mimics dopamine.Proceedings of the National Academy of Sciences, 1975
- Effect of butaclamol and its enantiomers upon striatal homovanillic acid and adenyl cyclase of olfactory tubercle in ratsLife Sciences, 1975
- Gamma-Aminobutyric Acid Binding to Receptor Sites in the Rat Central Nervous SystemProceedings of the National Academy of Sciences, 1974
- Mesencephalic dopamine neurons projecting to neocortexBrain Research, 1974
- Muscarinic Cholinergic Binding in Rat BrainProceedings of the National Academy of Sciences, 1974
- Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic DrugsProceedings of the National Academy of Sciences, 1974
- Provocation of Schizophrenic Symptoms by Intravenous Administration of MethylphenidateArchives of General Psychiatry, 1973
- DextroamphetamineArchives of General Psychiatry, 1972
- Chlorpromazie and Dopamine: Conformational Similarities that Correlate with the Antischizophrenic Activity of Phenothiazine DrugsProceedings of the National Academy of Sciences, 1971