Cloning of a potential cytochrome P450 from the Archaeon Sulfolobus solfataricus
- 22 April 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 384 (3), 235-239
- https://doi.org/10.1016/0014-5793(96)00322-5
Abstract
A gene, CYP119, for a potential cytochrome P450 has been isolated and sequenced from the extreme acidothermophilic archaeon Sulfolobus solfataricus. The gene predicts a polypeptide of 368 amino acids containing the consensus hemebinding sequence Phe-Gly-Xaa-Gly-Xaa-His-Xaa-Cys-Xaa-Gly-Xaa3-Ala-Arg-Xaa-Glu. It most closely resembles the cytochrome P450s found in the bacterium Bacillus subtilis, with which it shares 129 identical amino acid residues (35%). This first sequence of a potential archaeal cytochrome P450 represents an important step in tracing the complex evolutionary history of this biologically important enzyme family.Keywords
This publication has 13 references indexed in Scilit:
- Molecular evolution of P450 superfamily and P450‐containing monooxygenase systemsFEBS Letters, 1993
- Mouse liver cytochrome P-450 (P-450IIIAm1): its cDNA cloning and inducibility by dexamethasoneBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1992
- Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferasesMolecular Genetics and Genomics, 1991
- Variations and coding features of the sequence spanning the replication terminus of Bacillus subtllis 168 and W23 chromosomesGene, 1991
- [1] P450 gene nomenclature based on evolutionMethods in Enzymology, 1991
- Molecular cloning and characterization of the primary structure of the alkane hydroxylating cytochrome P-450 from the yeast Candida maltosaBiochemical and Biophysical Research Communications, 1989
- Gene Structure, Organization, And Expression In ArchaebacteriaCRC Critical Reviews in Microbiology, 1989
- Human P450PCN1: Sequence, Chromosome Localization, and Direct Evidence through cDNA Expression That P450PCN1 Is Nifedipine OxidaseDNA, 1988
- Transcription termination in the archaebacteriumSulfolobus: signal structures and linkage to transcription initiationNucleic Acids Research, 1988
- P450 GENES: STRUCTURE, EVOLUTION, AND REGULATIONAnnual Review of Biochemistry, 1987