Guinea pig maximization test open epicutaneous test and chamber test in induction of delayed contact hypersensitivity
- 1 October 1980
- journal article
- research article
- Published by Wiley in Contact Dermatitis
- Vol. 6 (5), 341-344
- https://doi.org/10.1111/j.1600-0536.1980.tb04960.x
Abstract
A comparison was made between the guinea pig maximization test (GPMT), open epicutaneous test (OET) and chamber test (CT); the allergens were neomycin sulfate and propylene glycol (PG). The sensitization rate for neomycin in petrolatum was 35% in GPMT, 25% in OET and 25% in CT. The corresponding figures for neomycin in PG were 30% in GPMT, 45% in OET and 32% in CT. PG caused no hypersensitivity in 118 guinea pigs. As a hygroscopic, irritant and penetrating vehicle, PG facilitates the induction of delayed contact allergy, especially in OET.Keywords
This publication has 9 references indexed in Scilit:
- Epicutaneous TestingAllergy, 1979
- Reactions to peroral propylene glycolContact Dermatitis, 1978
- Comparison of guinea pig sensitization methodsContact Dermatitis, 1976
- Sensitization to propantheline bromide, trichlorocarbanilide and propylene glycol in an antiperspirantContact Dermatitis, 1976
- Allergy to propantheline in an antiperspirant (Ercoril®lotion)Contact Dermatitis, 1975
- Skin reactions to propylene glycolContact Dermatitis, 1975
- Allergic Contact Dermatitis Due to Ingredients of VehiclesArchives of Dermatology, 1971
- The Identification of Contact Allergens by Animal Assay. the Guinea Pig Maximization Test**From the Department of Dermatology, University of Gothenburg, Sahlgrenska Sjukhuset, Gothenburg, Sweden and the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104.Journal of Investigative Dermatology, 1969
- STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDSThe Journal of Experimental Medicine, 1935