Thein vitro development of extended-release solid oral dosage forms
- 1 October 1985
- journal article
- conference paper
- Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 13 (5), 493-514
- https://doi.org/10.1007/bf01059332
Abstract
A system is described for developing extended-release products, based upon predicting or simulating the entire plasma level-time curve to be expected from the administration of a controlled-release oral dosage form. Termed “biorelevant dissolution,” it employs the product's in vitrodissolution behavior and the drug's pharmacokinetic parameters in conjunction with a classical pharmacokinetic model. The basic system is described along with some pertinent examples.Keywords
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