Runt Disease in Adult Tolerant Mice Induced by Intravenous Injection of Immunologically Competent Cells.

Abstract

Summary 1. Runt disease in adult mice of the Z(C3H) strain made previously tolerant of A tissue by antigenic exposure at birth was obtained by injecting these animals intravenously with large numbers of immunological competent spleen cells taken from A strain donors. 2. The main pathological findings in these animals were: a) marked body weight loss; b) Splenomegally and c) Atrophy of lymphoid tissue followed by death.