Absorption Enhancement of Rectally Infused Insulin by Sodium Tauro-24,25-Dihydrofusidate (STDHF) in Rats
- 1 January 1990
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 07 (2), 180-183
- https://doi.org/10.1023/a:1015837004307
Abstract
The bile salt derivative sodium tauro-24,25-dihydrofusidate (STDHF) has been reported to promote nasal absorption of insulin. In the present study the effect of STDHF on rectal insulin absorption was investigated in rats. At concentrations of 1 and 4% (w/v) it enhanced insulin bioavailability from 0.2 ± 0.2 (control) to 4.2 ± 3.2 and 6.7 ± 2.1%, respectively, as assessed by radioimmunoassay. Insulin preparations with STDHF reduced blood glucose concentrations considerably in a concentration-dependent way. Coadministration of STDHF with Na2EDTA (0.25%, w/v) tended to increase further insulin bioavailability and hypoglycemic response. Varying the site of rectal administration did not influence these parameters.Keywords
This publication has 15 references indexed in Scilit:
- Intestinal drug absorption enhancement: An overviewPharmacology & Therapeutics, 1989
- PREPRANDIAL INTRANASAL INSULINThe Lancet, 1988
- COMPARISON OF NASAL, RECTAL, BUCCAL, SUBLINGUAL AND INTRAMUSCULAR INSULIN EFFICACY AND THE EFFECTS OF A BILE-SALT ABSORPTION PROMOTER1988
- Site Dependence of Absorption-Promoting Actions of Laureth-9, Na Salicylate, Na2EDTA, and Aprotinin on Rectal, Nasal, and Buccal Insulin DeliveryPharmaceutical Research, 1987
- HUMAN INSULIN PLUS SODIUM GLYCOCHOLATE IN A NASAL SPRAY FORMULATION - IMPROVED BIOAVAILABILITY AND EFFECTIVENESS IN NORMAL SUBJECTS1987
- Effects of Sodium Taurodihydrofusidate on Nasal Absorption of Insulin in SheepJournal of Pharmaceutical Sciences, 1987
- RECTAL ADMINISTRATION OF INSULIN1984
- Avoidance of "first-pass" elimination of rectally administered lidocaine in relation to the site of absorption in rats.1983
- ENTERAL ADMINISTRATION OF INSULIN IN THE RATBritish Journal of Pharmacology, 1981
- Statistical Quality Control and Routine Data Processing for Radioimmunoassays and Immunoradiometric AssaysClinical Chemistry, 1974