Alloantisera can detect some of the variants of HLA DRw13 identified by oligotyping*
- 1 January 1992
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 39 (1), 42-47
- https://doi.org/10.1111/j.1399-0039.1992.tb02157.x
Abstract
Oligotyping has revealed a considerable polymorphism, pf HLA DRwl3; so far, 5 alleles coded by DRBI have been identified. An even greater number of haplotypes are apparent when considering the association of DRw13 with alleles coded by DRB3 and DQBI. Serology can now define some of these variants which had formerly escaped detection. We have tested by serology and by oligoprobes 66 genotyped Caucasoid cells comprising the known DR and DQ alleles. Among the 28 DRw6 cells, 10 different haplotype patterns were selected, of which 8 concern DRwl3 and 2 DRwl4. Four variants of DRw13 were represented: DRB1 *1301, * 1302. *1303 and 1305 associated with usual and with uncommon alleles belonging to DRB3 and to DQBI. We have centered our analysis on 19 sera of the XIth Workshop defining DRw6. Two sera (639. 826) were noteworthy since they reacted with certain subtypes of DRwl3 and with DRBI *1102, *1103 only, the other DR specificities remaining negative.Keywords
This publication has 15 references indexed in Scilit:
- HLA-DRw11, DQw7 has four cellular subtypes revealed by homozygous typing cells and undetected by restriction fragment length polymorphismHuman Immunology, 1991
- Diversity among DRw13 DQw7 haplotypes as revealed by serology Dw typing and restriction fragment length polymorphismHuman Immunology, 1991
- The complexity of DRw6 and DR5 haplotypes in American blacks demonstrated by serology, cellular typing, and restriction fragment length polymorphism analysisHuman Immunology, 1990
- A new HLA-DRB1 allele within the DRw52 supertypic specificity (DRw13-DwHAG): Sequencing and direct identification by oligonucleotide typingEuropean Journal of Immunology, 1990
- HLA-DR and -DQ epitopes and monoclonal antibody specificityImmunology Today, 1989
- DNA typing of DRw6 subtypes: Correlation with DRB1 and DRB3 allelic sequences by hybridization with oligonucleotide probesHuman Immunology, 1989
- Cellular and serological subtypes of HLA‐DR2Tissue Antigens, 1987
- Antigen Report: HLA-DRw6 and Its Subgroups HLA-DRw13 and HLA-DRw14Published by Springer Nature ,1984
- Definition of HLA-D with HTCPublished by Springer Nature ,1984
- A possible new HLA-DR alleleHuman Immunology, 1983