Induction of spectrin in erythroleukemic cells transformed by Friend virus.

Abstract

The presence and accumulation in murine erythroleukemic cells transformed by Friend virus of the erythrocyte membrane-associated protein spectrin was investigated. Spectrin was present in the uninduced cells and was induced 10- to 20-fold in dimethyl sulfoxide-treated differentiating cells. The intracellular concentration of spectrin reached a peak on the 3rd day of dimethyl sulfoxide treatment, after which it fell to levels found in mouse erythrocytes. The small subunit of spectrin was phosphorylated in the cells.