Pharmaceutical Applications of Microcalorimetry
- 1 January 1994
- journal article
- review article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 11 (6), 777-783
- https://doi.org/10.1023/a:1018957103417
Abstract
General principles and applications of microcalorimetry are reviewed. Microcalorimetry is useful in the study of physical, chemical, and biological drug interactions. The sensitivity of the present instrumentation is approximately 0.1 µW. With this high sensitivity, additional applications have been developed, including the interactions of drugs with food, lymphoma cells, microorganisms, blood, excipients, and cyclodextrin. A recent application of microcalorimetry is the measurement of degradation rates of drugs.Keywords
This publication has 26 references indexed in Scilit:
- Microcalorimetric studies of the initial interaction between antimycobacterial drugs and Mycobacterium aviumJournal of Antimicrobial Chemotherapy, 1990
- A microcalorimetric investigation of the binding of cinnarizine to cyclodextrinsJournal of Pharmaceutical and Biomedical Analysis, 1989
- Flow microcalorimetry as a tool for an improved analysis of antibiotic activity: The different stages of chloramphenicol actionCellular and Molecular Life Sciences, 1989
- Flow microcalorimetric assay of antibiotics —IV. Polymyxin B sulphate, neomycin sulphate, zinc bacitracin and their combinations with Escherichia coli suspended in buffer plus glucose mediumJournal of Pharmaceutical and Biomedical Analysis, 1989
- The Interaction of Dopexamine with Various Drugs and Excipients in Parenteral SolutionsJournal of Pharmacy and Pharmacology, 1988
- Effect of Gentamicin on Human Blood Cells Metabolism as Measured by MicrocalorimetryHuman Toxicology, 1987
- Microcalorimetric investigations of drug–albumin interactionsBiopharmaceutics & Drug Disposition, 1984
- Calorimetry as an Analytical Tool in Biochemistry and BiologyPublished by Wiley ,1976
- Mechanisms of Solid‐State Reactions of DrugsJournal of Pharmaceutical Sciences, 1976
- Stability of Solids and Solid Dosage FormsJournal of Pharmaceutical Sciences, 1974