Stem Cell Shape Regulates a Chondrogenic Versus Myogenic Fate Through Rac1 and N-Cadherin
- 15 January 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in The International Journal of Cell Cloning
- Vol. 28 (3), 564-572
- https://doi.org/10.1002/stem.308
Abstract
Human mesenchymal stem cells (hMSCs) are multipotent cells that can differentiate into many cell types. Chondrogenesis is induced in hMSCs cultured asKeywords
Funding Information
- NIH (EB00262, HL73305, GM74048)
- University of Pennsylvania Institute for Regenerative Medicine, and Center for Musculoskeletal Disorders
- NIH Medical Scientist Training Program
This publication has 46 references indexed in Scilit:
- N-Cadherin Interacts with Axin and LRP5 To Negatively Regulate Wnt/β-Catenin Signaling, Osteoblast Function, and Bone FormationMolecular and Cellular Biology, 2009
- Emergence of Patterned Stem Cell Differentiation Within Multicellular StructuresThe International Journal of Cell Cloning, 2008
- M-Cadherin Activates Rac1 GTPase through the Rho-GEF Trio during Myoblast FusionMolecular Biology of the Cell, 2007
- Cell shape regulates global histone acetylation in human mammary epithelial cellsExperimental Cell Research, 2007
- Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic CulturesScience, 2006
- An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signalingThe Journal of cell biology, 2006
- RhoA GTPase Regulates M-Cadherin Activity and Myoblast FusionMolecular Biology of the Cell, 2006
- Smad-dependent and Smad-independent pathways in TGF-β family signallingNature, 2003
- Rho GTPases in cell biologyNature, 2002
- A Role for N-Cadherin in the Development of the Differentiated Osteoblastic PhenotypeJournal of Bone and Mineral Research, 2000