Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels
- 3 June 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 283 (2), 259-262
- https://doi.org/10.1016/0014-5793(91)80602-y
Abstract
A new 1,4‐dihydropyridine photoaffinity ligand, [3H]diazipine, has been assessed by binding and photolabeling, and compared with a currently used [3H]Diazipine reversibly binds to skeletal muscle Ca2+ channels with a similar affinity of [3H]azidopine, but [3H]diazipine labels the channels two times more efficiently and no release of the incorporated amount is observed after dithiothreitol treatment.Keywords
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