Effect of Xanthophyll on the Utilization of Carotene and Vitamin A by the Rat

Abstract
Large amounts of xanthophyll (lutein) administered with β-carotene or vitamin A decrease the utilization of these substances for tissue storage of vitamin A in rats. They have no effect on the rate of disappearance of vitamin A already present in the tissues, indicating that the inhibitory action may occur in the alimentary tract. The inhibitory effect is not overcome by extra vitamin E administered as α-tocopheryl acetate. The effect of the xanthophyll is not due to a specific impairment of the enzymatic mechanism for the conversion of carotene to vitamin A.