Suppressive Effect of 1,25-Dihydroxyvitamin D3on Circulating Parathyroid Hormone in Acute Renal Failure

Abstract

To elucidate whether the kidney hormone 1,25-dihydroxyvitamin D₃ [1,25-(OH)₂D₃) directly feedback regulates the secretion of parathyroid hormone (PTH), 10 patients with acute oliguric renal failure were studied. Serum ionized calcium (Ca⁺⁺) was kept constant and subnormal by continuous peritoneal dialysis with low Ca⁺⁺ dialysis fluid. In the control period (24 h), PTH was found to be constantly increased. In the treatment period (30 h), five patients received 250 ng 1,25–3 iv every 6 h, while five comparable patients served as controls. A significant suppression of PTH-levels was observed in the treatment group after a lag-period of 12–18 h during stable low Ca⁺⁺. In the control group, PTH remained constantly increased throughout the trial. Since Ca⁺⁺ was kept constant by the dialysis procedure, the observed reduction of PTH-levels cannot be explained by the calcemic effect of 1,25-(OH)₂D₃. The data suggest that 1,25-(OH)₂D₃ directly feedback regulates PTH secretion in humans with normal parathyroid glands.