Building blood vessels—stem cell models in vascular biology
Open Access
- 29 May 2007
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 177 (5), 751-755
- https://doi.org/10.1083/jcb.200701146
Abstract
Spheroids of differentiating embryonic stem cells, denoted embryoid bodies, constitute a high-quality model for vascular development, particularly well suited for loss-of-function analysis of genes required for early embryogenesis. This review examines vasculogenesis and angiogenesis in murine embryoid bodies and discusses the promise of stem cell-based models for the study of human vascular development.Keywords
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