DNA content and DNA synthesis in the myocardium of rats after induced renal hypertension

Abstract

Values of induced renal hypertension were found to rise above 200 mm Hg after three weeks; these values changed only slightly during the nine months of experiment. Fibre thickness was found to correspond to hypertension. DNA synthesis took place first in endothelial and interstitial cells and decreased after three months. Only then could a significant DNA synthesis in myocardial cells be observed. There was no polyploidization of the myocardial nuclei.