Effect of an adrenergic blocking agent on vascular alterations associated with endotoxin shock

Abstract

The effects of Dibenzyline on the vascular changes associated with endotoxin shock were studied in the dog. Pretreatment with Dibenzyline augmented venous return by decreasing pooling of blood in the liver and probably other areas. The precipitous drop in systemic arterial pressure usually associated with the administration of endotoxin was absent in the Dibenzyline-treated dog, but arterial pressure dropped to the same level as in the nontreated animals within 30 min. Treatment with Dibenzyline had no effect (in 1 hr) on the change in pH, hematocrit, or heart rate.