Tumor Grading by Implantation in Embryos. II. Grading of Some Human Astrocytomas2

Abstract

Six human astrocytomas were graded by a system based on assessment ot cellular responses of 16to 18-hour chick embryos to implanted tumors. Such grading of astrocytomas did not correlate with the grading system of Kernohan et al. Whereas the Kernohan grad ing of the astrocytomas did not correlate with the survival times of the patients, grading in embryos showed a positive correlation. The survival times decreased with increase of the product of grade in embryo × age of the patient. This grading system may allow prognostic assessments of individual cases.