INCOMPLETE HEPATIC INACTIVATION OF HORMONE PRODUCED BY THE INTRASPLENICALLY GRAFTED OVARY IN THE MOUSE1,2,3

Abstract

The wts. of the uterus and vagina of spayed mice, spayed mice bearing an autoplastically grafted ovary in the spleen, and unoperated animals were compared.. The organs of graft-bearing mice weighed significantly less than those of the controls; the organs of the castrates were in turn significantly lighter in wt. than those of the graft-bearing mice. Histological examination of the uterus and vagina of the graft-bearing mice support the conclusion that sex hormone produced by an ovary situated in the spleen is not totally removed by the liver. The avg. graft wt. was 6 times that of a control ovary. A suggestion of negative correlation is seen between the wts. of the grafts and the corresponding uteri.