AN ALTERNATIVE COUPLING REACTION OF MITOCHONDRIA-BOUND TRANSAMINASE AND TRICABOXYLIC ACID CYCLE AND ITS METABOLIC ROLE

Abstract

Stoichiometric interconversion of glutamate and aspartate by the coupling reactions between GOTm and TCA cycle takes place in the isolated mitochondrial system. Significance of the GOTM cycle for amino acid metabolism may concern with nonessential amino acid catabolism and anabolism and with the effective pathway, through which the amino group of glutamate turns into urea without liberation of ammonia. Elementary reactions of GOTM strongly occur in mitochondria, but the physiological significance is not known.