Role of training conditions in discrimination of central nervous system stimulants by rats
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 73 (3), 295-303
- https://doi.org/10.1007/bf00422421
Abstract
Amphetamine and some related compounds were compared in rats trained to discriminate (+)-amphetamine (0.4,1.0 or 1.6 mg/kg) or cocaine (10.0 mg/kg) from the nondrug condition in a standard, two-bar procedure with food reinforcement (n=5–6). Amphetamine and cocaine were generalized completely with each other, in most cases at dose levels which did not greatly reduce the overall numbers of responses. The ED50 values for amphetamine and cocaine varied with the drug and dose used for training, and it was concluded that the stimuli produced by the two drugs were similar but may not be identical. There was an excellent correlation between ED50 values derived from indices of barselection and percentage-responding on the drug-appropriate bar. Apomorphine was generalized with amphetamine only in the rats trained with the higher doses of amphetamine, and only when administered in doses which greatly reduced the overall number of responses. Para-hydroxyamphetamine increased responding on the drug-appropriate bar only when administered in high doses to the rats trained with the lowest dose of amphetamine (0.4 mg/kg). The results strengthen the evidence that the particular drug and dose level used for training can significantly affect the outcome of generalization tests, and challenge the notion that the discriminability of drugs is an immutable property that is amenable to absolute measurement.Keywords
This publication has 35 references indexed in Scilit:
- Factors regulating drug cue sensitivity: The effect of training dose in fentanyl-saline discriminationNeuropharmacology, 1980
- Differential stimulus attributes of chlordiazepoxide and pentobarbitalNeuropharmacology, 1979
- Drug-induced cues in studying mechanisms of drug actionNeuropharmacology, 1979
- Discriminative stimulus properties of cocaine: Neuropharmacological characteristics as derived from stimulus generalization experimentsPharmacology Biochemistry and Behavior, 1979
- Discriminative stimulus properties of cocaine and d-amphetamine, and antagonism by haloperidol: A comparative studyNeuropharmacology, 1978
- Effects of opiates on the discriminative stimulus properties of dopamine agonistsPharmacology Biochemistry and Behavior, 1978
- Drug discrimination and generalization in pigeonsPharmacology Biochemistry and Behavior, 1977
- Rate-dependent effects of drugs: A review of the literaturePharmacology Biochemistry and Behavior, 1976
- Role of dopamine in d-amphetamine-induced discriminative respondingPharmacology Biochemistry and Behavior, 1975
- Discriminative stimulus properties of d-amphetamine and related compounds in ratsPharmacology Biochemistry and Behavior, 1974