A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors
- 1 July 1981
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 37 (7), 755-756
- https://doi.org/10.1007/bf01967963
Abstract
The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect is unrelated to β-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.Keywords
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