STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. VII. THE ANTIMALARIAL ACTIVITY OF PAMAQUINE 123

Abstract

Pamaquine at max. tolerated doses is incapable of effecting interruption of the erythrocytic schizo-gonous cycle of vivax and falciparum malaria. Pamaquine has a curative action in primary attacks of sporozoite-induced vivax malaria when the drug is given at high dosage, in conjunction with quinine, for 14 days. It appears that curative effects observed by other workers at lower dosages are attributable to greater strain susceptibilities, to admn. of the drug at a later stage of the disease, or to a lesser density of underlying tissue infection. There is no correlation between plasma pamaquine concn. and antimalarial effect, whether suppressive or curative.