Antibacterial Activity of Serum of Normal Subjects after Oral Doses of Demethylchlortetracycline, Chlortetracycline and Oxytetracycline
- 28 May 1959
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 260 (22), 1099-1104
- https://doi.org/10.1056/nejm195905282602201
Abstract
IN a previous paper from this laboratory, Kunin and Finland1 reported that the new tetracycline antibiotic, demethylchlortetracycline, given to normal persons in single or repeated oral doses, produced much higher and better sustained levels of antibacterial activity in the serum than corresponding doses of tetracycline. The superior activity was demonstrated in comparisons employing standard strains of streptococcus, staphylococcus and Bacillus cereus in twofold dilutions of serum in broth, and also by comparison of the concentrations of antibiotic activity in serum as determined by an agar cup-plate diffusion method using B. cereus as the test strain and expressing the results in . . .Keywords
This publication has 3 references indexed in Scilit:
- DemethylchlortetracyclineNew England Journal of Medicine, 1958
- Enhancement of Tetracycline Blood LevelsNew England Journal of Medicine, 1958
- Blood Levels and Urinary Excretion in Normal Subjects after Ingestion of Tetracycline Analogues.Experimental Biology and Medicine, 1954